Compare the 2026 Mercedes-Benz E-Class E350 vs E450 - Lincoln, NE

2026 E-Class E 350 vs E 450 4MATIC

2026 Mercedes-Benz E-Class E 350

  • Standard Engine2.0L I-4 Turbo w/ Mild Hybrid
  • Horsepower255 hp
  • MPG (city/hwy) *25 / 33
  • Seats5
  • DrivetrainRear-Wheel Drive
  • Wheels Size18-inch 5-spoke

2026 Mercedes-Benz E-Class E 450 4MATIC

  • Standard Engine3.0L I-6 Turbo w/ Mild Hybrid
  • Horsepower375 hp
  • MPG (city/hwy) *23 / 33
  • Seats5
  • Drivetrain4MATIC® All-Wheel Drive
  • Wheels Size19-inch AMG 5-spoke

Specs at a Glance

The Mercedes-Benz E-Class continues to set the benchmark for the midsize luxury sedan category. With its unique blend of cutting-edge innovation and high-end comfort, it remains a tough act for competitors to follow. If you are currently in the market for a new E-Class, you will likely find yourself choosing between the E 350 and the more powerful E 450. Here is a closer look at how these two trim levels stack up.

Performance

The E 350 is powered by a 2.0-liter turbocharged four-cylinder engine featuring mild-hybrid technology. This setup produces a capable 255 horsepower and 295 lb-ft of torque, offering a perfect balance of daily drivability and impressive fuel efficiency. A refined nine-speed automatic transmission handles the gear shifts, while standard adaptive suspension dampers ensure the ride stays silky smooth. While rear-wheel drive is standard, drivers can opt for the 4MATIC AWD system for enhanced traction.

For those who crave more spirit behind the wheel, the E 450 is the clear step up. It features a larger 3.0-liter turbocharged inline-six engine, also assisted by a mild-hybrid system. This potent powerplant delivers a jump to 375 horsepower and 369 lb-ft of torque. While it utilizes the same seamless nine-speed automatic transmission found in the E 350, the E 450 comes standard with all-wheel drive for maximum control.

Appearance

It is easy to see why so many drivers are captivated by this sedan's sophisticated silhouette. The E 350 now features sporty AMG styling as standard equipment, giving the car a more aggressive and muscular presence on the road. The front fascia is defined by a signature star-pattern grille, complemented by a standard panoramic roof and 18-inch alloy wheels. You can expect the E 450 to carry over these same elegant and athletic design cues.

Features

Inside the E 350, you'll find a sanctuary of premium materials and essential comforts, such as heated front seats and dual-zone automatic climate control. The cabin is also a hub for modern technology, headlined by a 14.4-inch touchscreen that utilizes augmented-reality navigation for easier city driving. Standard highlights include a 360-degree camera system, a hands-free trunk, and a wireless smartphone charger. The E 450 shares this identical list of high-tech amenities and luxuries.

Visit Us In Lincoln, NE

If you have any further questions regarding the 2026 Mercedes-Benz E-Class lineup or want to schedule a test drive, please reach out to the team at Husker Auto Group.

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Base MSRP excludes transportation and handling charges, destination charges, taxes, title, registration, preparation and documentary fees, tags, labor and installation charges, insurance, and optional equipment, products, packages and accessories. Actual vehicle price may vary by Dealer.

* EPA estimated fuel economy. Compare the estimated mpg to the estimated mpg of other vehicles. You may get different mileage depending on how fast you drive, weather conditions and trip length. Your actual highway mileage will probably be less than the highway estimate.Back to content

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